CD320 Antibody (C-term) [APR03779G]

CD320 Antibody (C-term) [APR03779G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 28991

Clone: Polyclonal

Gene Name: CD320

Gene ID: 51293

Function: Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389) . Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213) . Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470) . Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631) . Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631) . CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631) .

Summary: Tissue Location: Detected in the germinal center (GC) of lymphoid follicles (at protein level) (PubMed:11418631) . Expressed abundantly on follicular dendritic cells (FDCs) (PubMed:10727470)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A