CD40 Antibody [FGK45] (preservative free) | 36-148

CD40 Antibody [FGK45] (preservative free) | 36-148 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: Recombinant mouse CD40 fusion protein.

Research Area: Cancer, Immunology, Innate Immunity, Functional Assays

Tested Application: Flow, FUNC

Application: Functional Application: Activates B and NK cells in vivo and in vitro.

Specificiy: Recognizes mouse CD40.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: >95% (SDS-PAGE)

Clonality: Monoclonal

Clone: FGK45

Isotype: IgG2a

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Liquid. In PBS. Preservative free formulation.

Concentration: 1 mg/ml

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.

Alternate Name: Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.