CD42b Polyclonal Antibody | E-AB-11281

CD42b Polyclonal Antibody | E-AB-11281 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Antigen CD42b alpha, BDPLT1, BDPLT3, BSS, CD 42b, CD42b alpha, CD42B, CD42b antigen, DBPLT3, GLYCOCALICIN, Glycoprotein Ib (platelet) alpha polypeptide, Glycoprotein Ibalpha, GP Ib alpha, GP1B, GP1BA, GPIb alpha, GPIbA, MGC34595, Platelet glycoprotein Ib alpha chain, Platelet glycoprotein Ib alpha polypeptide, Platelet membrane glycoprotein 1b alpha subunit, VWDP

Application: WB, IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Immunology

Background: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.

Concentration: 0.8 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human GP1BA

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 72 kDa

Molecular Weight(Observed): N/A