CD44 Antibody [F10-44-2] | 99-374

CD44 Antibody [F10-44-2] | 99-374 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Ma's Night Monkey

Homology: N/A

Immunogen: Purified human T cells

Research Area: Signal Transduction, Signal Transduction

Tested Application: Flow

Application: CD44 Antibody [F10-44-2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, CMCD, cytotoxicity, depletion, adhesion, activation, purification, and blocking assays.

Specificiy: CD44

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [F10-44-2]

Isotype: IgG2a

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

Concentration: 0.1 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Pgp-1, H-CAM, ECMR-III, HUTCH-1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD44, also known as phagocytic glycoprotein-1 (Pgp-1) , exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing, and adhesion during hematopoiesis and lymphocyte activation.