CD45.1 Antibody [A20] (APC) | 76-548

CD45.1 Antibody [A20] (APC) | 76-548 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Mouse

Homology: N/A

Immunogen: N/A

Research Area: Immunology

Tested Application: Flow

Application: N/A

Specificiy: The A20 monoclonal antibody reacts with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A) .

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Clonality: Monoclonal

Clone: A20

Isotype: Mouse IgG2a, kappa

Conjugate: APC

Physical State: liquid

Buffer: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Concentration: batch dependent

Storage Condition: The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

Alternate Name: loc, B220, Cd45, L-CA, Ly-5, T200, CD45R, Lyt-4, Ptprc

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The A20 monoclonal antibody reacts with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A) . It does not cross-react with cells that express CD45.2. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The A20 antibody inhibits some of the B lymphocytes responses, from CD45.1-expressing mice, to lipopolysaccharides and antigens.