CD49e Antibody [5H10.27] | 98-807

CD49e Antibody [5H10.27] | 98-807 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: C57BL/6 x A/J F1 mouse mast cell line MC/9

Research Area: Cancer, Signal Transduction

Tested Application: Flow

Application: CD49e Antibody [5H10.27] for use in flow cytometry, immunohistochemistry, costimulation, blocking, and adhesion assays.

Specificiy: CD49e

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [5H10.27]

Isotype: IgG2a

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Integrin alpha5, VLA-5alpha

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The monoclonal antibody 5H10.27 reacts with the alpha5 chain (VLA-5) of the CD49e/CD29 heterodimeric fibronectin receptor. It is expressed on thymocytes, activated T cells, mast cells, and a variety of mouse cell lines. Soluble 5H10.27 antibody inhibits VLA-5-mediated functions in vitro. Immobilized 5H10.27 has also been demonstrated to costimulate the proliferative response of CD8+ T cells to plate-bound anti-CD3 monoclonal antibody.