CD49f Antibody [4F10] (FITC) | 99-548

CD49f Antibody [4F10] (FITC) | 99-548 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: SW1222 human colorectal cell line

Research Area: Cell Cycle, Signal Transduction

Tested Application: IHC-Fr, Flow, Blocking, IP, Stimulation, Activity

Application: CD49f Antibody [4F10] for use in flow cytometry and immunohistochemistry assays.

Specificiy: CD49f

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [4F10]

Isotype: IgG2b

Conjugate: FITC

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: Lot specific

Storage Condition: Store vial at 2-8˚C

Alternate Name: Integrin alpha6 chain, VLA-6 alpha chain, platelet gpIc

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD49f is the 125 kDa integrin alpha6 chain which associates noncovalently with the integrin beta1 subunit (CD29) and with the integrin beta4 (CD104) chain to form, respectively, the very late antigen-6 (VLA-6) and alpha6beta4 integrin heterodimers. VLA-6 is expressed on thymocytes, T lymphocytes, monocytes, and platelets. CD49f/CD29 expression is upregulated on activated T lymphocytes and memory T cells. VLA-6 serves as the laminin receptor on platelets, monocytes, and T cells. VLA-6-mediated binding to laminin provides a costimulatory signal to T cells for activation and proliferation.