CD6 polyclonal Antibody | BS61731

CD6 polyclonal Antibody | BS61731 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: CD6 is a type I transmembrane glycoprotein that is present on mature thymocytes, peripheral T cells and a subset of B cells. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T-cell activation and the size difference between the CD6 forms is due in part to differences in phosphorylation state. CD6 protein contains a 24-amino acid signal sequence, 3 extracellular “scavenger receptor cysteine-rich” (SRCR) domains, a membrane-spanning domain, and a 44-amino acid cytoplasmic domain. CD6 shows significant homology to CD5. CD6, which is also found in brain and B cell chronic lymphocytic leukemias, plays an important role in interactions of thymocytes with thymic epithelial cells. CD6 molecules can physically associate with the TCR/ CD3 complex.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD6 polyclonal Antibody detects endogenous levels of CD6 protein.

Molecular Weight: ~ 71 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: T-cell differentiation antigen CD6; T12; TP120; CD6; Soluble CD6; CD6

Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human CD6.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: