CD62E/CD62P Antibody [1.2B6] (PE-Cy5) | 99-407

CD62E/CD62P Antibody [1.2B6] (PE-Cy5) | 99-407 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Pig

Homology: N/A

Immunogen: TNF stimulated human endothelial cells

Research Area: Immunology, Signal Transduction

Tested Application: IHC, ICC, Flow

Application: CD62E/CD62P Antibody [1.2B6] for use in flow cytometry assays.

Specificiy: CD62E/CD62P

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [1.2B6]

Isotype: IgG1

Conjugate: PE-Cy5

Physical State: Liquid

Buffer: Supplied in PBS/NaN3 and a stabilizing agent

Concentration: Lot specific

Storage Condition: Store vial at 2-8˚C

Alternate Name: E-selectin, P-selectin, ELAM-1, LECAM-2, PADGEM, GMP-140, LECAM-3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin, also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1) . It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and is absent on leukocytes. Like other selectins, CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces, a prerequisite for leukocyte extravasation into tissues. CD62P is a 140 kDa membrane glycoprotein formerly known as platelet activation-dependent granule membrane protein (PADGEM) or GMP-140. It is expressed on platelets, megakaryocytes, and epithelium. It is thought to mediate the adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses and of activated platelets to neutrophils and monocytes in hemostasis. The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P.