CD71 polyclonal Antibody | BS90256

CD71 polyclonal Antibody | BS90256 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: ICC IHC FC

Application Range: ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CD71 polyclonal Antibody detects endogenous levels of CD71 protein.

Molecular Weight: 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TR, TfR, TfR1, Trfr, sTfR, TFRC, CD 71, CD71, CD71 antigen, IMD46, OTTHUMP00000208523, OTTHUMP00000208524, OTTHUMP00000208525, p90, sTfR, T9, TFR 1, TfR, TfR1, TFR1, TFRC, TR, Transferrin receptor (p90 CD71), Transferrin receptor protein 1, serum form, Trfr,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: Immune checkpoint signaling in the Tumor Microenvironment,