CD74, human recombinant | 7317

HLA class II histocompatibility antigen gamma chain isoform b, also known as CD74, is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. It is upregulated in several cancers and is also expressed by nonimmune cells during inflammation. Recombinant human CD74 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

7317 | CD74 human recombinant DataSheet

Biomolecule/Target: CD74

Synonyms: HLA class II histocompatibility antigen gamma chain isoform b, DHLAG, HLADG, Ia-GAMMA, II

Alternates names: HLA class II histocompatibility antigen gamma chain isoform b, DHLAG, HLADG, Ia-GAMMA, II

Taglines: A transmembrane protein present on APCs with chaperoning functions.

NCBI Gene ID #: 959

NCBI Gene Symbol: CD40-L

Gene Source: Human

Accession #: P29965

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: < 1.0 EU per 1 microgram of protein

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 20.6 kDa (183 aa, 73-232 aa + His tag), confirmed by MALDI-TOF.

Concentration: 0.5 mg/ml

Appearance: Liquid

Physical form description: 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 1 mM DTT and 30% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MGSQQQGRLD KLTVTSQNLQ LENLRMKLPK PPKPVSKMRM ATPLLMQALP MGALPQGPMQ NATKYGNMTE DHVMHLLQNA DPLKVYPPLK GSFPENLRHL KNTMETIDWK VFESWMHHWL LFEMSRHSLE QKPTDAPPKE SLELEDPSSG LGVTKQDLGP VPM