CD86 Antibody [GL-1 (GL1) ] | 76-597

CD86 Antibody [GL-1 (GL1) ] | 76-597 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: N/A

Research Area: Innate Immunity

Tested Application: Flow, Func, IHC, IF

Application: N/A

Specificiy: The GL-1 monoclonal antibody reacts specifically with the mouse B7-2 (also known as CD86) , a costimulatory molecule expressed by B and T lymphocytes, macrophages (thioglycollate-induced from peritoneum) , astrocytes and dendritic cells.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Clonality: Monoclonal

Clone: GL-1 (GL1)

Isotype: Rat IgG2a, kappa

Conjugate: Unconjugated

Physical State: liquid

Buffer: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Concentration: batch dependent

Storage Condition: The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

Alternate Name: B7, B70, MB7, B7-2, B7.2, CLS1, Ly58, ETC-1, Ly-58, MB7-2, Cd28l2, TS/A-2, Cd86

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The GL-1 monoclonal antibody reacts specifically with the mouse B7-2 (also known as CD86) , a costimulatory molecule expressed by B and T lymphocytes, macrophages (thioglycollate-induced from peritoneum) , astrocytes and dendritic cells. The memory CD4+ T lymphocytes express CD86 (as mRNA and protein) . CD86, and the B7-1 (CD 80) molecule, are ligands for CD152 and CD28, and influence the costimulatory interactions between lymphocytes B and T. B7-2 is also involved in the mouse natural killer cell-mediated cytotoxicity. The GL-1 antibody blocks the mixed lymphocyte reaction (MLR) and inhibits the T-cells stimulation by antigen-presenting cells. Mixtures of anti-B7-1 antibody and GL-1 were reported to inhibit the interaction between CD125 and its ligand with the in vivo priming of cytotoxic T lymphocytes.