Cdc7 (F35) polyclonal Antibody | BS2447

Cdc7 (F35) polyclonal Antibody | BS2447 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins) . Cdc7 kinase was also found to be important in meiosis, checkpoint responses, maintenance of chromosome structure, and repair.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cdc7 (F35) polyclonal Antibody detects endogenous levels of Cdc7 protein.

Molecular Weight: ~ 64 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cell division cycle 7-related protein kinase; CDC7-related kinase; HsCdc7; huCdc7; CDC7; CDC7L1

Immunogen: Synthetic peptide, corresponding to amino acids 11-50 of Human Cdc7.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: