Cdk4 Inhibitor | B2928

Cdk4 Inhibitor is an indolocarbazole which is a potent, selective and ATP competitive cyclin D1/CDK4 inhibitor. It has an IC₅₀ value of 76 nM. It inhibits tumor cell growth, arrests tumor cells at the G1 phase, and inhibits pRb phosphorylation in HCT-116 and NCI-H460 cells with IC₅₀ < 3.0 µM.

Cdk4 Inhibitor is an indolocarbazole which is a potent, selective and ATP competitive cyclin D1/CDK4 inhibitor. It has an IC₅₀ value of 76 nM. It inhibits tumor cell growth, arrests tumor cells at the G1 phase, and inhibits pRb phosphorylation in HCT-116 and NCI-H460 cells with IC₅₀ < 3.0 µM.

B2928 | Cdk4 Inhibitor DataSheet

Alternate Name/Synonyms: 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; K00024; Cyclin-dependent kinase 4 Inhibitor

Appearance: Solid

Formulation:

CAS Number: 546102-60-7

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₀H₁₀BrN₃O₂

Molecular Weight: 404.22

Cell-Permeable?: True

Purity: 95%

Solubilities: ~30 mg/ml in DMSO and DMF in 0, ~0.25 mg/ml in in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent cyclin D1-CDK4 inhibitor

MDL Number:

PubChem CID: 5330797

SMILES: C1=CC=C2C(=C1)C3=C4C(=C5C6=C(C=C(C=C6)Br)NC5=C3N2)C(=O)NC4=O

InChi: InChI=1S/C20H10BrN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26)

InChi Key: NMFKDDRQSNVETB-UHFFFAOYSA-N