Celastrol | 1940

Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC₅₀ = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC₅₀ = 230 nM) and LPS-induced NF-κB activation (IC₅₀ = 270 nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC₅₀ = 2.5 µM) and lipid peroxidation induced by ADP and Fe²⁺ in rat liver mitochondria (IC₅₀ = 7 µM).

Celastrol is an antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC₅₀ = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC₅₀ = 230 nM) and LPS-induced NF-κB activation (IC₅₀ = 270 nM).

1940 | Celastrol DataSheet

Alternate Name/Synonyms: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid

Appearance: Red solid

Formulation: N/A

CAS Number: 34157-83-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₈O₄

Molecular Weight: 450.61

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (45 mg/ml) or Ethanol (30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An Antioxidant, anti-inflammatory and immunosuppressive agent

MDL Number: MFCD03424073

PubChem CID: 122724

SMILES: CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O

InChi: InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

InChi Key: KQJSQWZMSAGSHN-JJWQIEBTSA-N