CEP-28122 | B2503

CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). Displays antitumor activity in experimental models of human cancers.

CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). Displays antitumor activity in experimental models of human cancers.

B2503 | CEP-28122 DataSheet

Alternate Name/Synonyms: (1S,2S,3R,4R)-3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-bicyclo[2.2.1]hept-5-ene-2-carboxamide; CEP28122

Appearance: Crystalline solid

Formulation:

CAS Number: 1022958-60-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₅ClN₆O₃

Molecular Weight: 539.1

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A highly potent and selective ALK inhibitor

MDL Number:

PubChem CID: 57325421

SMILES: COC1=C(C=CC2=C1CCC(CC2)N3CCOCC3)NC4=NC=C(C(=N4)NC5C6CC(C5C(=O)N)C=C6)Cl

InChi: InChI=1S/C28H35ClN6O3/c1-37-25-20-8-7-19(35-10-12-38-13-11-35)6-4-16(20)5-9-22(25)32-28-31-15-21(29)27(34-28)33-24-18-3-2-17(14-18)23(24)26(30)36/h2-3,5,9,15,17-19,23-24H,4,6-8,10-14H2,1H3,(H2,30,36)(H2,31,32,33,34)/t17-,18+,19+,23+,24-/m1/s1

InChi Key: LAJAFFLJAJMYLK-CVOKMOJFSA-N