CEP-32496 | 9615

CEP-32496 specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase. It inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene.

CEP-32496 specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase. It inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene.

9615 | CEP-32496 DataSheet

Alternate Name/Synonyms: 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea; AC013773

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1188910-76-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₂F₃N₅O₅

Molecular Weight: 517.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase.

MDL Number: N/A

PubChem CID: 56846693

SMILES: CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F

InChi: InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33)

InChi Key: DKNUPRMJNUQNHR-UHFFFAOYSA-N