CEP-33779 | B2473

CEP-33779 is a potent and orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors, reduces angiogenesis, and reduces proliferation of tumor cells.

CEP-33779 is a potent and orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors, reduces angiogenesis, and reduces proliferation of tumor cells.

B2473 | CEP-33779 DataSheet

Alternate Name/Synonyms: N-(3-(4-methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; CEP33779

Appearance: Yellow solid

Formulation:

CAS Number: 1257704-57-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₆N₆O₂S

Molecular Weight: 462.57

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A highly selective JAK2 inhibitor

MDL Number:

PubChem CID: 57336812

SMILES: CN1CCN(CC1)C2=CC(=CC=C2)NC3=NN4C=CC=C(C4=N3)C5=CC=C(C=C5)S(=O)(=O)C

InChi: InChI=1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-6-3-5-19(17-20)25-24-26-23-22(7-4-12-30(23)27-24)18-8-10-21(11-9-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)

InChi Key: RFZKSQIFOZZIAQ-UHFFFAOYSA-N