CEP-37440 | B2504

CEP-37440 is a potent and selective dual FAK/ALK inhibitor with IC₅₀ s of 2.3 nM (FAK) and 120 nM (ALK cellular IC₅₀ in 75% human plasma). The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. It blocks the proliferation of inflammatory and triple-negative breast cancer cell lines but not normal breast epithelial cells.

CEP-37440 is a potent and selective dual FAK/ALK inhibitor with IC₅₀ s of 2.3 nM (FAK) and 120 nM (ALK cellular IC₅₀ in 75% human plasma). The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. It blocks the proliferation of inflammatory and triple-negative breast cancer cell lines but not normal breast epithelial cells.

B2504 | CEP-37440 DataSheet

Alternate Name/Synonyms: 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-benzamide; CEP37440

Appearance: Crystalline solid

Formulation:

CAS Number: 1391712-60-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₈ClN7O₃

Molecular Weight: 580.13

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective Dual FAK/ALK inhibitor

MDL Number:

PubChem CID: 71721648

SMILES: CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C4=C(CC(CCC4)N5CCN(CC5)CCO)C=C3)OC

InChi: InChI=1S/C30H38ClN7O3/c1-32-29(40)23-7-3-4-9-25(23)34-28-24(31)19-33-30(36-28)35-26-11-10-20-18-21(6-5-8-22(20)27(26)41-2)38-14-12-37(13-15-38)16-17-39/h3-4,7,9-11,19,21,39H,5-6,8,12-18H2,1-2H3,(H,32,40)(H2,33,34,35,36)/t21-/m0/s1

InChi Key: BCSHRERPHLTPEE-NRFANRHFSA-N