CEP-40783 | B2505

CEP-40783 (RDX-106) is a potent and selective inhibitor of AXL and c-Met with IC₅₀ values of 7 nM and 12 nM, respectively. In AXL-transfected 293GT cells, CEP-40783 was 27-fold more active compared to recombinant enzyme with an IC50 value of 0.26 nM. CEP-40783 displays potent AXL and c-Met pharmacodynamic and anti-tumor efficacy in established tumor xenograft models.

B2505 | CEP-40783 DataSheet

Alternate Name/Synonyms: RXDX106; CEP40783; N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide; RXDX-106

Appearance: Crystalline solid

Formulation:

CAS Number: 1437321-24-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₂₆F₂N₄O₆

Molecular Weight: 588.56

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >5 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective inhibitor of AXL and c-Met

MDL Number:

PubChem CID: 71576419

SMILES: CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F

InChi: InChI=1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-21(24)25/h5-17H,1-4H3,(H,35,38)

InChi Key: FKCWHHYUMFGOPY-UHFFFAOYSA-N