Cepharanthine | B3042

Cepharanthine is an alkaloid extracted from the plant Stephania cepharantha Hayata. It shows antimalarial, antiviral, anti-inflammatory, and antitumor activities. The IC₅₀ values against different strains of Plasmodium falciparum range beween 0.927 μM and 3.06 μM. It (10 μM) causes cell cycle arrest at G(1) phase, induces apoptosis and decreases the expression of STAT3 in SaOS2 Human osteosarcoma cells. It (20 mg/kg/day, ip for 19 days) significantly reduces the volume and weight of the tumor in nude mouse xenografts of SaOS2 cells. It reduces pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 in RAW264.7 cells and mouse models. It inhibits the HIV-1 entry process by reducing plasma membrane fluidity. It inhibits the cytopathic effect in 2019-nCoV-related coronaviruses (2019-nCoVr) infected cells.

Cepharanthine is an alkaloid extracted from the plant Stephania cepharantha Hayata. It shows antimalarial, antiviral, anti-inflammatory, and antitumor activities. The IC₅₀ values against different strains of Plasmodium falciparum range beween 0.927 μM and 3.06 μM. It (10 μM) causes cell cycle arrest at G(1) phase, induces apoptosis and decreases the expression of STAT3 in SaOS2 Human osteosarcoma cells. It (20 mg/kg/day, ip for 19 days) significantly reduces the volume and weight of the tumor in nude mouse xenografts of SaOS2 cells. It reduces pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 in RAW264.7 cells and mouse models. It inhibits the HIV-1 entry process by reducing plasma membrane fluidity. It inhibits the cytopathic effect in 2019-nCoV-related coronaviruses (2019-nCoVr) infected cells.

B3042 | Cepharanthine DataSheet

Alternate Name/Synonyms: O-Methylcepharanoline; (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; [14aS-(14aR*,26aS*)]-2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl- H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2′,3′:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline; CEP

Appearance: White to Beige powder

Formulation:

CAS Number: 481-49-2

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₃₇H₃₈N₂O₆

Molecular Weight: 606.7

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~2 mg/ml in ethanol, ~5 mg/ml in DMSO, ~10 mg/ml in DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An alkaloid with antimalarial, antiviral, anti-inflammatory, and antitumor activity

MDL Number: MFCD00210482

PubChem CID: 10206

SMILES: CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3

InChi: InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1

InChi Key: YVPXVXANRNDGTA-WDYNHAJCSA-N