Cercosporamide | 9662

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinases (Mnk1 and Mnk2), and JAK3 (IC₅₀ values are 115, 11, and 31 nM for Mnk1, Mnk2 and JAK3, respectively). Also inhibits Pkc1. Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro.

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinases (Mnk1 and Mnk2), and JAK3 (IC₅₀ values are 115, 11, and 31 nM for Mnk1, Mnk2 and JAK3, respectively). Also inhibits Pkc1. Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro.

9662 | Cercosporamide DataSheet

Alternate Name/Synonyms: (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide

Appearance: Yellow lyophilized solid

Formulation: N/A

CAS Number: 131436-22-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₃NO₇

Molecular Weight: 331.28

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~ 3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) inhibitor

MDL Number: N/A

PubChem CID: 10019578

SMILES: CC(=O)C1=C(C=C2C(C1=O)(C3=C(C=C(C(=C3O2)C(=O)N)O)O)C)O

InChi: InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,19-21H,1-2H3,(H2,17,23)

InChi Key: GEWLYFZWVLXQME-UHFFFAOYSA-N