Cerebral 1 (L310) polyclonal Antibody | BS3101

Cerebral 1 (L310) polyclonal Antibody | BS3101 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC:1:50~1:200

Background: Cerebral 1 also called hucep-1, KIAA0409 or RRP8, is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cerebral 1 (L310) polyclonal Antibody detects endogenous levels of Cerebral 1 protein.

Molecular Weight: ~ 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin; RRP8; KIAA0409; NML; hucep-1; HUCE1; hucep1; RRP-8

Immunogen: Synthetic peptide, corresponding to amino acids 291-340 of Human Cerebral 1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: