CERS4 Polyclonal Antibody | E-AB-13375

CERS4 Polyclonal Antibody | E-AB-13375 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ceramide synthase 4, CerS4, FLJ12089, LAG1 homolog ceramide synthase 4, LAG1 longevity assurance homolog 4, LAG1, S. cerevisiae, homolog of, 4, LASS 4, LASS4, LASS4 LAG1 homolog ceramide synthase 4, LASS4, TRAM homolog 1, Trh 1, Trh1

Application: WB, IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Metabolism, Signal Transduction

Background: The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.

Concentration: 0.9 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human CERS4

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 46 kDa

Molecular Weight(Observed): N/A