Cerulenin | 1579

Antibiotic. Fatty acid synthase (FAS) inhibitor, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or downstream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).

Cerulerin is an antibiotic and a Fatty acid synthase (FAS) inhibitor, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase, thus inhibiting protein acylation.

1579 | Cerulenin DataSheet

Alternate Name/Synonyms: 2,3-Epoxy-4-oxo-7,10-dodecadienamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 17397-89-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₇NO₃

Molecular Weight: 223.3

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (20 mg/ml) or EtOH (20 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A FAS inhibitor

MDL Number: MFCD00077686

PubChem CID: 272023

SMILES: CC=CCC=CCCC(=O)C1C(O1)C(=O)N

InChi: InChI=1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6, 10-11H,4,7-8H2,1H3,(H2,13,15)

InChi Key: GVEZIHKRYBHEFX-UHFFFAOYSA-N