CES2 Antibody (Center) [APR07088G]

CES2 Antibody (Center) [APR07088G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CES2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-369 amino acids from the Central region of human CES2.

Cellular Localisation: Endoplasmic reticulum lumen

Molecular Weight: 61807

Clone: Polyclonal

Gene Name: CES2 (HGNC:1864)

Gene ID: 8824

Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443) . Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443) . Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105) . Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2- arachidonoylglycerol and prostaglandins (PubMed:21049984) .

Summary: Tissue Location: Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Cocaine esterase, Carboxylesterase 2, CE-2, hCE-2, Methylumbelliferyl-acetate deacetylase 2, CES2, ICE