Cetirizine dihydrochloride | B2993

Cetirizine is a selective histamine H1 receptor antagonist with a Ki of 6 nM. It is a highly efficacious, well-tolerated, treatment for the management of Allergic Rhinitis. Cetirizine exerts anti-inflammatory effects apart from H1 antagonism. It significantly decreases the amounts of leukotriene B4 generated from neutrophil granulocytes. It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED₅₀ value of 100 μg/kg, p.o.).

Cetirizine is a selective histamine H1 receptor antagonist with a Ki of 6 nM. It is a highly efficacious, well-tolerated, treatment for the management of Allergic Rhinitis. Cetirizine exerts anti-inflammatory effects apart from H1 antagonism. It significantly decreases the amounts of leukotriene B4 generated from neutrophil granulocytes. It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED₅₀ value of 100 μg/kg, p.o.).

B2993 | Cetirizine dihydrochloride DataSheet

Alternate Name/Synonyms: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid,dihydrochloride; (+/-)-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid, dihydrochloride; UCB-P 071; Zyrtec; Reactine

Appearance: White Powder

Formulation:

CAS Number: 83881-52-1

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₂₁H₂₇Cl₃N₂O₃

Molecular Weight: 461.81

Cell-Permeable?: True

Purity: >98.0%

Solubilities: ~10 mg/ml in PBS, pH 7.2, ~12 mg/ml in DMSO, ~3 mg/ml in DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective histamine H1 receptor antagonist

MDL Number: MFCD00941428

PubChem CID: 55182

SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl

InChi: InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H

InChi Key: PGLIUCLTXOYQMV-UHFFFAOYSA-N