CFI-400945 | B1287

CFI-400945 is a potent, ATP-competitive inhibitor of PLK4 (Polo-like kinase 4) (Ki = 0.2 nM). Displays anticancer properties. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells.

CFI-400945 is a potent, ATP-competitive inhibitor of PLK4 (Polo-like kinase 4) (Ki = 0.2 nM). Displays anticancer properties. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells.

B1287 | CFI-400945 DataSheet

Alternate Name/Synonyms: (1R,2S)-2-(3-((E)-4-(((2S,6R)-2,6-dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1338806-76-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₃₄N₄O₃

Molecular Weight: 534.65

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive inhibitor of PLK4 (Polo-like kinase 4)

MDL Number: N/A

PubChem CID: 58486178

SMILES: CC1CN(CC(O1)C)CC2=CC=C(C=C2)C=CC3=NNC4=C3C=CC(=C4)C5CC56C7=C(C=CC(=C7)OC)NC6=O

InChi: InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1

InChi Key: DADASRPKWOGKCU-FVTQAUBDSA-N