cFMS Receptor Inhibitor IV | B2922

cFMS Receptor Inhibitor IV is a furan carboxamide compound that is a potent, reversible, and ATP-competitive inhibitor of cFMS (Colony-stimulating Factor-1 Receptor) Tyrosine Kinase. It blocks cFMS autophosphorylation in CSF-1/M-CSF-stimulated HEK-293 cells and in cell-free in vitro kinase assays with IC₅₀ values of 76 nM and 17 nM respectively.

cFMS Receptor Inhibitor IV is a furan carboxamide compound that is a potent, reversible, and ATP-competitive inhibitor of cFMS (Colony-stimulating Factor-1 Receptor) Tyrosine Kinase. It blocks cFMS autophosphorylation in CSF-1/M-CSF-stimulated HEK-293 cells and in cell-free in vitro kinase assays with IC₅₀ values of 76 nM and 17 nM respectively.

B2922 | cFMS Receptor Inhibitor IV DataSheet

Alternate Name/Synonyms: cFMS Receptor Tyrosine Kinase Inhibitor; 5-cyano-N-(2,5-di(piperidin-1-yl)phenyl)furan-2-carboxamide; CSF-1 Receptor Inhibitor IV

Appearance: Solid

Formulation:

CAS Number: 959626-45-0

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₂H₂₆N₄O₂

Molecular Weight: 378.47

Cell-Permeable?: True

Purity: 97%

Solubilities: 5 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of cFMS/CSF-1R

MDL Number:

PubChem CID: 28408236

SMILES: C1CCN(CC1)C2=CC(=C(C=C2)N3CCCCC3)NC(=O)C4=CC=C(O4)C#N

InChi: InChI=1S/C22H26N4O2/c23-16-18-8-10-21(28-18)22(27)24-19-15-17(25-11-3-1-4-12-25)7-9-20(19)26-13-5-2-6-14-26/h7-10,15H,1-6,11-14H2,(H,24,27)

InChi Key: FQGXFVDABCBEFW-UHFFFAOYSA-N