CFTR Antibody | 7717

CFTR Antibody | 7717 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Sheep: (100%) , Rabbit: (100%) , Bovine: (95%) , Pig: (89%) , Horse: (89%) , Guinea pig: (89%)

Immunogen: CFTR antibody was raised against an 18 amino acid peptide near the carboxy terminus of human CFTR.
The immunogen is located within amino acids 1290 - 1340 of CFTR.

Research Area: Signal Transduction

Tested Application: E, WB, IHC-P, IF

Application: CFTR antibody can be used for detection of CFTR by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: CFTR antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1308 - Human Small Intestine Tissue Lysate

Positive Control 2: Cat. No. 11-801 - Human Small Intestine Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 163 kDa
Observed: 160 kDa

Validation: N/A

Isoform: N/A

Purification: CFTR antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: CFTR Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: CFTR antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: CFTR Antibody: CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C member 7, CFTR

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance (1, 2) . CFTR functions as a chloride channel and controls the regulation of other transport pathways (3) . Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations (1) .