CFTR Inhibitor-172 | 2487

A potent, reversible, selective, CFTR chloride channel blocker. Inhibits CFTR short-circuit current in < 2 minutes in a voltage-independent manner (Ki = ~ 300 nM). At concentrations fully inhibiting CFTR, CFTR(inh)-172 does not block increase of cellular cAMP or inhibit non-CFTR Cl(-) channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K(⁺) channels, or a series of other transporters.

CFTR Inhibitor-172 is a potent, reversible, selective, CFTR chloride channel blocker. Inhibits CFTR short-circuit current in < 2 minutes in a voltage-independent manner (Ki = ~ 300 nM).

2487 | CFTR Inhibitor-172 DataSheet

Alternate Name/Synonyms: 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid; CFTR(inh)-172

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 307510-92-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₀F₃NO₃S₂

Molecular Weight: 409.4

Cell-Permeable?: No

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Apotent, CFTR chloride channel blocker

MDL Number: MFCD06411408

PubChem CID: 1554208

SMILES: C1=CC(=CC(=C1)N2C(=O)C(=CC3=CC=C(C=C3)C(=O)O)SC2=S)C(F)(F)F

InChi: InChI=1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-

InChi Key: JIMHYXZZCWVCMI-ZSOIEALJSA-N