CFTR Inhibitor, GlyH-101 | 2863

CFTR Inhibitor II, or GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM). GlyH-101 binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport.

CFTR Inhibitor II, or GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM). GlyH-101 binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport.

2863 | CFTR Inhibitor, GlyH-101 DataSheet

Alternate Name/Synonyms: 2-​[(3,​5-​dibromo-​2,​4-​dihydroxyphenyl)methylene]hydrazide N-​2-​naphthalenyl-​glycine; GlyH-101; Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II

Appearance: Yellow solid

Formulation: N/A

CAS Number: 328541-79-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₅Br₂N₃O₃

Molecular Weight: 493.15

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor

MDL Number: MFCD01532954

PubChem CID: 11260414

SMILES: C1=CC=C2C=C(C=CC2=C1)NCC(=O)NNC=C3C=C(C(=C(C3=O)Br)O)Br

InChi: InChI=1S/C19H15Br2N3O3/c20-15-8-13(18(26)17(21)19(15)27)9-23-24-16(25)10-22-14-6-5-11-3-1-2-4-12(11)7-14/h1-9,22-23,27H,10H2,(H,24,25)/b13-9-

InChi Key: FLGYCSPPJQJZCH-LCYFTJDESA-N