cGAMP disodium salt | 2435

A potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-β. Plays a role in bacterial chemotaxis and colonization.

cGAMP is a potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-β.

2435 | cGAMP disodium salt DataSheet

Alternate Name/Synonyms: Cyclic (Adenosine Monophosphate-Guanosine Monophosphate); cyclic GMP-AMP; c-(GpAp)

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 849214-04-6 (free acid)

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂N₁₀O₁₃P₂ . 2Na

Molecular Weight: 718.37

Cell-Permeable?: No

Purity: ≥98% by HPLC

Solubilities: Water

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent STING ligand

MDL Number: N/A

PubChem CID: 71563406

SMILES: C1C2C(C(C(O2)N3C=NC4=C3NC(=NC4=O)N)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C6N=CN=C7N)O)OP(=O)(O1)O)O)O

InChi: InChI=1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1

InChi Key: XRILCFTWUCUKJR-INFSMZHSSA-N