CGI-1746 | 9647

CGI-1746 is a potent, cell-permeable, ATP-competitive BTK inhibitor (IC₅₀ = 1.9 nM). It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.

CGI-1746 is a potent, cell-permeable, ATP-competitive BTK inhibitor (IC₅₀ = 1.9 nM). It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.

9647 | CGI-1746 DataSheet

Alternate Name/Synonyms: 4-tert-butyl-N-[2-methyl-3-[4-methyl-6-[4-(morpholine-4-carbonyl)anilino]-5-oxopyrazin-2-yl]phenyl]benzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 910232-84-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₄H₃₇N₅O₄

Molecular Weight: 579.69

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, cell-permeable, ATP-competitive BTK inhibitor

MDL Number: N/A

PubChem CID: 24857323

SMILES: CC1=C(C=CC=C1NC(=O)C2=CC=C(C=C2)C(C)(C)C)C3=CN(C(=O)C(=N3)NC4=CC=C(C=C4)C(=O)N5CCOCC5)C

InChi: InChI=1S/C34H37N5O4/c1-22-27(7-6-8-28(22)37-31(40)23-9-13-25(14-10-23)34(2,3)4)29-21-38(5)33(42)30(36-29)35-26-15-11-24(12-16-26)32(41)39-17-19-43-20-18-39/h6-16,21H,17-20H2,1-5H3,(H,35,36)(H,37,40)

InChi Key: JIFCFQDXHMUPGP-UHFFFAOYSA-N