CGP-57380 | 9661

CGP-57380 is a cell-permeable Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC₅₀ = 2.2 μM). Displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases.

CGP-57380 is a cell-permeable Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC₅₀ = 2.2 μM). Displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases.

9661 | CGP-57380 DataSheet

Alternate Name/Synonyms: N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine

Appearance: Yellow solid

Formulation: N/A

CAS Number: 522629-08-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₉FN₆

Molecular Weight: 244.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Inhibitor of MAP-kinase interacting kinase-1 (Mnk1)

MDL Number: N/A

PubChem CID: 11644425

SMILES: C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F

InChi: InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)

InChi Key: UQPMANVRZYYQMD-UHFFFAOYSA-N