CH-223191 | 2723

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It blocks activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (IC₅₀ = 0.03 µM). It also blocks TCDD-mediated translocation and DNA-binding activity of the AhR. Displays no AhR agonist activity (at concentrations up to 100 μM). Through its effects on AhR, CH 223191 suppresses Th17 cell differentiation both in vitro and in vivo and alters the expression of homeobox transcription factors necessary for the differentiation of embryonic stem cells to cardiomyocytes.

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It blocks activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (IC₅₀ = 0.03 µM). It also blocks TCDD-mediated translocation and DNA-binding activity of the AhR. Displays no AhR agonist activity (at concentrations up to 100 μM).

2723 | CH-223191 DataSheet

Alternate Name/Synonyms: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Appearance: Orange solid

Formulation: N/A

CAS Number: 301326-22-7

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₉N₅O

Molecular Weight: 333.39

Cell-Permeable?: Yes

Purity: ³95%

Solubilities: DMSO (>30 mg/ml) or EtOH (~3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and specific aryl hydrocarbon receptor (AhR) antagonist.

MDL Number: MFCD00377884

PubChem CID: 3091786

SMILES: CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C

InChi: InChI=1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)

InChi Key: LKTNEXPODAWWFM-UHFFFAOYSA-N