Ch 55 | B3366

Ch 55 | B3366

Description: Ch 55 is a synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Ch 55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM).

Alternate Name/Synonyms: 4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid

Appearance: Pale yellow solid

Formulation:

CAS Number: 110368-33-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₈O₃

Molecular We4.47

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >15 mg/ml Ethanol >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A potent RAR agonist

MDL Number:

PubChem CID: 6184667

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/6184667

SMILES: CC(C)(C)C1=CC(=CC(=C1)C(=O)\C=C\C1=CC=C(C=C1)C(O)=O)C(C)(C)C

InChi: InChI=1S/C24H28O3/c1-23(2,3)19-13-18(14-20(15-19)24(4,5)6)21(25)12-9-16-7-10-17(11-8-16)22(26)27/h7-15H,1-6H3,(H,26,27)/b12-9+

InChi Key: FOUVTBKPJRMLPE-FMIVXFBMSA-N

Category: Biochemica