CH5183284 | B1649

CH5183284 is a selective and orally available FGFR1/2/3 inhibitor. The IC50 values of CH5183284 on the enzyme activity of FGFR1/2/3/4 were 9.3, 7.6, 22, and 290 nM, respectively.

CH5183284 is a selective and orally available FGFR1/2/3 inhibitor. The IC50 values of CH5183284 on the enzyme activity of FGFR1/2/3/4 were 9.3, 7.6, 22, and 290 nM, respectively.

B1649 | CH5183284 DataSheet

Alternate Name/Synonyms: CH5183284; CH-5183284; CH 5183284; Debio-1347; Debio 1347; Debio1347; FF284; FF-284; FF 284; (5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone

Appearance: Solid

Formulation: N/A

CAS Number: 1265229-25-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₆N₆O

Molecular Weight: 356.38

Cell-Permeable?: Yes

Purity: >98%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective inhibitor of the kinase activity of FGFRs

MDL Number: NA

PubChem CID: 66555680

SMILES: CC1=NC2=C(N1)C=C(C=C2)N3C(=C(C=N3)C(=O)C4=CC5=CC=CC=C5N4)N

InChi: InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)

InChi Key: BEMNJULZEQTDJY-UHFFFAOYSA-N