CH5424802 | 2867

CH5424802 is a potent, selective, ATP-competitive inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). It displays potent antitumor activity against RET-rearranged non-small cell lung cancer (NSCLC).

CH5424802 is a potent, selective, ATP-competitive inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). It displays potent antitumor activity against RET-rearranged non-small cell lung cancer (NSCLC).

2867 | CH5424802 DataSheet

Alternate Name/Synonyms: 9-Ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; Alectinib; AF-802

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1256580-46-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₄N₄O₂

Molecular Weight: 482.62

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (2 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective, ATP-competitive ALK inhibitor

MDL Number: N/A

PubChem CID: 49806720

SMILES: CCC1=C(C=C2C(=C1)C(=O)C3=C(C2(C)C)NC4=C3C=CC(=C4)C#N)N5CCC(CC5)N6CCOCC6

InChi: InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3

InChi Key: KDGFLJKFZUIJMX-UHFFFAOYSA-N