CH7057288 | B2514

CH7057288 as a potent and selective TRK (tropomyosin receptor kinase) inhibitor that may be useful in inhibiting TRK fusion-positive cancer cell growth. CH7057288 shows selective inhibitory activity against TRKA, TRKB, and TRKC in cell-free kinase assays and suppresses proliferation of TRK fusion–positive cell lines, but not that of TRK-negative cell lines.

CH7057288 as a potent and selective TRK (tropomyosin receptor kinase) inhibitor that may be useful in inhibiting TRK fusion-positive cancer cell growth. CH7057288 shows selective inhibitory activity against TRKA, TRKB, and TRKC in cell-free kinase assays and suppresses proliferation of TRK fusion–positive cell lines, but not that of TRK-negative cell lines.

B2514 | CH7057288 DataSheet

Alternate Name/Synonyms: CH-7057288; N-(tert-butyl)-2-((6,6-dimethyl-8-(methylsulfonamido)-11-oxo-6,11-dihydronaphtho[2,3-b]benzofuran-3-yl)ethynyl)-6-methylisonicotinamide

Appearance: Crystalline solid

Formulation:

CAS Number: 2095616-82-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₁N₃O₅S

Molecular Weight: 569.68

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective tropomyosin receptor kinase (TRK) inhibitor

MDL Number:

PubChem CID: 131839646

SMILES: CC1=NC(=CC(=C1)C(=O)NC(C)(C)C)C#CC2=CC3=C(C=C2)C4=C(O3)C(C5=C(C4=O)C=CC(=C5)NS(=O)(=O)C)(C)C

InChi: InChI=1S/C32H31N3O5S/c1-18-14-20(30(37)34-31(2,3)4)16-21(33-18)10-8-19-9-12-24-26(15-19)40-29-27(24)28(36)23-13-11-22(35-41(7,38)39)17-25(23)32(29,5)6/h9,11-17,35H,1-7H3,(H,34,37)

InChi Key: DCGOHGQJHJXBGW-UHFFFAOYSA-N