Chaetocin | 2283

A fungal mycotoxin that inhibits the histone lysine methyltransferase (HKMT) SU(VAR)3-9 (IC₅₀ = 0.8 μM). Inhibits other Lys9-specific HMTs, including G9a (IC₅₀ = 2.5 μM) and DIM5 (IC₅₀ = 3 μM). Selectivity for Lys9-HMTs is indicated by higher IC₅₀ values (>90 μM) for Lys20-specific PRSET7, Lys27-specific EZH2, and Lys4-specific SET7/9.

Chaetocin is a fungal mycotoxin that inhibits the histone lysine methyltransferase (HKMT) SU(VAR)3-9 (IC₅₀ = 0.8 μM). Inhibits other Lys9-specific HMTs, including G9a (IC₅₀ = 2.5 μM) and DIM5 (IC₅₀ = 3 μM).

2283 | Chaetocin DataSheet

Alternate Name/Synonyms: (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)­-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl­)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio­-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4­,4'-tetrone

Appearance: Off-white solid

Formulation: N/A

CAS Number: 28097-03-2

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₃₀H₂₈N₆O₆S₄

Molecular Weight: 696.84

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~7 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A selective histone lysine methyltransferase (HKMT) inhibitor

MDL Number: MFCD00133163

PubChem CID: 161591

SMILES: CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C

InChi: InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3

InChi Key: PZPPOCZWRGNKIR-UHFFFAOYSA-N