CHCHD6 Antibody | 7133

CHCHD6 Antibody | 7133 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6.
The immunogen is located within amino acids 20 - 70 of CHCHD6.

Research Area: Cancer, Cell Cycle

Tested Application: E, WB

Application: CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: CHCHD6 is predicted to not cross-react to other members of the CHCHD family.

Positive Control 1: Cat. No. 1220 - SK-N-SH Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 26 kDa

Validation: N/A

Isoform: N/A

Purification: CHCHD6 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: CHCHD6 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: CHCHD6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: CHCHD6 Antibody: CHCM1, PPP1R23, CHCM1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial, Coiled coil helix cristae morphology protein 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1) - (helix 1) - (coiled coil 2) - (helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.