CHD3 Antibody [4F6B11] | 23-968

CHD3 Antibody [4F6B11] | 23-968 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Recombinant protein of human CHD3

Research Area: Immunology

Tested Application: WB, IHC, Flow

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Flow: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: 293T

Positive Control 2: HL-60

Positive Control 3: Jurkat

Positive Control 4: K-562

Positive Control 5: A375

Positive Control 6: LO2

Molecular Weight: Observed: 270kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Monoclonal

Clone: [4F6B11]

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: Mi-2a, Mi2-ALPHA, SNIBCPS, ZFH, chromodomain-helicase-DNA-binding protein 3, ATP-dependent helicase CHD3, CHD-3, hZFH, mi-2 autoantigen 240 kDa protein, zinc finger helicase, zinc-finger helicase (Snf2-like)

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.