CHD3 Polyclonal Antibody | E-AB-63718

CHD3 Polyclonal Antibody | E-AB-63718 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: CHD3, Mi-2a, Mi2-ALPHA, ZFH

Application: WB

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Immunology

Background: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A synthetic peptide of human CHD3 (NP_001005273.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:200-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 222 kDa/226 kDa/233 kDa

Molecular Weight(Observed): 280 kDa