Chelerythrine chloride | 2064

Cell-permeable. A selective protein kinase C (PKC) inhibitor (IC₅₀ =0.66 µM). Chelerythrine is at least 100-fold more selective for PKCs than for other kinases. It induces apoptotic cell death in polymorphonuclear leukocyte through activation of caspase-3. In addition, Chelerythrine treated cells underwent apoptosis, with features that suggest involvement of the mitochondrial pathway, and through a mechanism that involves inhibition of the anti-apoptotic inhibitor BclXL.

Chelerythrine chloride is a selective protein kinase C (PKC) inhibitor (IC₅₀ =0.66 µM). Chelerythrine is at least 100-fold more selective for PKCs than for other kinases. It induces apoptotic cell death in polymorphonuclear leukocyte through activation of caspase-3.

2064 | Chelerythrine chloride DataSheet

Alternate Name/Synonyms: 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

Appearance: Yellow to orange solid

Formulation: N/A

CAS Number: 3895-92-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₁₈NO₄Cl

Molecular Weight: 383.82

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 10 mg/ml) or H₂O (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective protein kinase C (PKC) inhibitor

MDL Number: MFCD00060717

PubChem CID: 72311

SMILES: C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]

InChi: InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1

InChi Key: WEEFNMFMNMASJY-UHFFFAOYSA-M