CHIA polyclonal Antibody | BS6942

CHIA polyclonal Antibody | BS6942 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Chitinases are ubiquitous chitin-fragmenting hydrolases. The chitinase Chitotriosidase is capable of cleaving natural chitin and chitin-like substrates in humans and may play a role in immunity against pathogens containing chitin. Activated human macrophages secrete chitotriosidase, and increased plasma levels of chitotriosidase are a feature of patients suffering from Gaucher’s disease. Expression of mouse Chitotriosidase is restricted to brain, skin, bone marrow, kidney, tongue, stomach and testis. The homology between chitotriosidase and chitinases found in lower organisms is significant. Acidic mammalian chitinase precursor (AMCase) degrades chitotriose and chitin. AMCase is highly expressed in stomach tissues and is primarily a secreted protein. It is involved in Th2-mediated inflammation and may play a role in asthma and allergic diseases.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CHIA polyclonal Antibody detects endogenous levels of CHIA protein.

Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Acidic mammalian chitinase; AMCase; Lung-specific protein TSA1902; CHIA

Immunogen: Recombinant full length Human CHIA.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: