CHIR-98014 | 2595

Cell-permeable. CHIR-98014 is a potent, selective and ATP-competitive inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively). In addition, CHIR-98014 displays 500 to greater than 1000-fold selectivity towards GSK3 than other protein kinases such as cdc2 and ERK2. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.

CHIR-98014 is a potent, selective and ATP-competitive inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively). In addition, CHIR-98014 displays 500 to greater than 1000-fold selectivity towards GSK3 than other protein kinases such as cdc2 and ERK2.

2595 | CHIR-98014 DataSheet

Alternate Name/Synonyms: 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine; CT 98014

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 556813-39-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₇Cl₂N₉O₂

Molecular Weight: 486.31

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~ 4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent GSK3 inhibitor

MDL Number: N/A

PubChem CID: 53396311

SMILES: C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N

InChi: InChI=1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)

InChi Key: MDZCSIDIPDZWKL-UHFFFAOYSA-N