Chk2 Inhibitor | 1702

A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively.

Chk2 Inhibitor is a cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1.

1702 | Chk2 Inhibitor DataSheet

Alternate Name/Synonyms: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 516480-79-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₄CIN₃O₂

Molecular Weight: 363.8

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Chk2 inhibitor

MDL Number: MFCD08276917

PubChem CID: 9969021

SMILES: C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl

InChi: InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)

InChi Key: UXGJAOIJSROTTN-UHFFFAOYSA-N