CHMP4B+CHMP4C Polyclonal Antibody | BS65990

CHMP4B+CHMP4C Polyclonal Antibody | BS65990 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CHMP4B+CHMP4C Polyclonal Antibody detects endogenous levels of CHMP4B+CHMP4C protein.

Molecular Weight: 25kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SNF7 homolog associated with Alix 3; C20orf178; Charged multivesicular body protein 4b; Charged multivesicular body protein 4c; CHMP 4B; CHMP 4C; CHMP4A; Chromatin modifying protein 4B; Chromatin modifying protein 4C; CTPP3; dJ553F4.4; hSnf7 2; hSnf7 3; hVps32; MGC22825; Shax1; Shax3; SNF7 2; SNF7 3; SNF7; Snf7 homologue associated with Alix 1; Vacuolar protein sorting associated protein 7 2; Vacuolar protein sorting associated protein 7 3.

Immunogen: KLH conjugated synthetic peptide derived from human CHMP4B/CHMP4C:101-200/224

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: