Cholesteryl hemisuccinate | B1978

Cholesteryl hemisuccinate is a useful cholesterol-based detergent that increases the stability of G protein-coupled receptors (GPCRs). Together with mutagenesis studies and recent GPCR structures, it has been determined that stabilization is attained through a combination of specific sterol binding to GPCRs and modulation of micelle morphology.

Cholesteryl hemisuccinate is a useful cholesterol-based detergent that increases the stability of G protein-coupled receptors (GPCRs). Together with mutagenesis studies and recent GPCR structures, it has been determined that stabilization is attained through a combination of specific sterol binding to GPCRs and modulation of micelle morphology.

B1978 | Cholesteryl hemisuccinate DataSheet

Alternate Name/Synonyms: 3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; CHS

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1510-21-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₅₀O₄

Molecular Weight: 486.73

Cell-Permeable?: No

Purity: ≥95%

Solubilities: EtOH (warm; with faint turbidity)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A detergent that stabilizes GPCRs

MDL Number: MFCD00037705

PubChem CID: 65082

SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C

InChi: InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1

InChi Key: WLNARFZDISHUGS-MIXBDBMTSA-N